Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557276 | 1.00 | IDH1 (0.44) | IDH1TYK2TDP2JAK1STAT3 | |
| SCHEMBL24557284 | 0.90 | TDP2 (0.42) | IDH1TDP2MMP13PLK1PRKDC | |
| SCHEMBL29638496 | 0.88 | SRC (0.46) | TYK2JAK1KCNH2PLK1PRKDC | |
| SCHEMBL24557271 | 0.88 | SRC (0.46) | TYK2JAK1KCNH2PLK1PRKDC | |
| SCHEMBL29638480 | 0.85 | BTK (0.45) | TYK2JAK1PLK1PRKDCPIK3CA | |
| SCHEMBL24557272 | 0.85 | BTK (0.45) | TYK2JAK1PLK1PRKDCPIK3CA | |
| SCHEMBL29638395 | 0.84 | LYN (0.42) | GSK3BPLK1PRKDCPIK3CALYN | |
| SCHEMBL24557289 | 0.84 | LYN (0.42) | GSK3BPLK1PRKDCPIK3CALYN | |
| SCHEMBL24557282 | 0.84 | POLB (0.42) | TYK2JAK1PLK1PRKDCPIK3CA | |
| SCHEMBL29638556 | 0.84 | POLB (0.42) | TYK2JAK1PLK1PRKDCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |