Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638346 | 0.86 | ABL1 (0.47) | TYK2ABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24557316 | 0.86 | ABL1 (0.47) | TYK2ABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29638315 | 0.85 | ABL1 (0.46) | TYK2ABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24557318 | 0.85 | ABL1 (0.46) | TYK2ABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29638378 | 0.83 | TYK2 (0.46) | TYK2JAK2ABL1SMN1; SMN2 | |
| SCHEMBL29638385 | 0.81 | ABL1 (0.47) | ABL1NPC1RAB9AMAP4K1MAPK1 | |
| SCHEMBL24557362 | 0.77 | TYK2 (0.48) | TYK2JAK1JAK2STAT3 | |
| SCHEMBL29638386 | 0.77 | TYK2 (0.48) | TYK2JAK1JAK2STAT3 | |
| SCHEMBL24557310 | 0.76 | PIK3CD (0.46) | ABL1MAP4K1 | |
| SCHEMBL24557268 | 0.76 | TYK2 (0.49) | TYK2JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |