Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638449 | 0.89 | TYK2 (0.42) | TYK2JAK1PLK1SRCBTK | |
| SCHEMBL24557255 | 0.89 | TYK2 (0.42) | TYK2JAK1PLK1SRCBTK | |
| SCHEMBL29638436 | 0.87 | TYK2 (0.51) | TYK2JAK1 | |
| SCHEMBL24557300 | 0.87 | TYK2 (0.51) | TYK2JAK1 | |
| SCHEMBL29638331 | 0.86 | JAK1 (0.43) | TYK2JAK1JAK2SRCBTK | |
| SCHEMBL24557265 | 0.86 | JAK1 (0.43) | TYK2JAK1JAK2SRCBTK | |
| SCHEMBL29638454 | 0.85 | TYK2 (0.41) | TYK2PLK1SRCBTK | |
| SCHEMBL29638443 | 0.84 | TYK2 (0.51) | TYK2JAK1JAK3SRC | |
| SCHEMBL29638317 | 0.83 | TYK2 (0.42) | TYK2JAK1JAK2 | |
| SCHEMBL29638361 | 0.83 | TYK2 (0.38) | TYK2JAK1PLK1JAK3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |