SCHEMBL29638436

SCHEMBL29638436

COc1c(F)cccc1-n1[nH]c(=O)c2cnc(Nc3cc(C)nc(C)n3)cc21

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 20/20 0.51
JAK1 P23458 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24557300 1.00 TYK2 (0.51) TYK2JAK1
SCHEMBL29638443 0.89 TYK2 (0.51) TYK2JAK1
SCHEMBL29638449 0.89 TYK2 (0.42) TYK2JAK1
SCHEMBL24557255 0.89 TYK2 (0.42) TYK2JAK1
SCHEMBL29638454 0.89 TYK2 (0.41) TYK2
SCHEMBL29638317 0.89 TYK2 (0.42) TYK2JAK1
SCHEMBL29638372 0.87 TYK2 (0.42) TYK2JAK1
SCHEMBL29638389 0.85 BTK (0.48) TYK2JAK1
SCHEMBL29638423 0.83 TYK2 (0.59) TYK2JAK1
SCHEMBL29638361 0.83 TYK2 (0.38) TYK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022136914-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2022-06-30 WO disclosed