Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638436 | 0.89 | TYK2 (0.51) | TYK2JAK1 | |
| SCHEMBL24557300 | 0.89 | TYK2 (0.51) | TYK2JAK1 | |
| SCHEMBL29638379 | 0.89 | TYK2 (0.41) | TYK2JAK1SRCMAPK13ABL1 | |
| SCHEMBL29638317 | 0.87 | TYK2 (0.42) | TYK2JAK1 | |
| SCHEMBL29638372 | 0.84 | TYK2 (0.42) | TYK2JAK1SRCJAK3 | |
| SCHEMBL29638420 | 0.83 | BTK (0.47) | TYK2JAK1SRCLYN | |
| SCHEMBL29638423 | 0.83 | TYK2 (0.59) | TYK2JAK1 | |
| SCHEMBL29638361 | 0.83 | TYK2 (0.38) | TYK2JAK1SRCMAPK13ABL1 | |
| SCHEMBL24557255 | 0.81 | TYK2 (0.42) | TYK2JAK1SRCLYN | |
| SCHEMBL29638449 | 0.81 | TYK2 (0.42) | TYK2JAK1SRCLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |