Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557268 | 1.00 | TYK2 (0.49) | TYK2PIK3C3POLBGAAJAK2 | |
| SCHEMBL29638361 | 0.87 | TYK2 (0.38) | TYK2POLBGAAJAK1 | |
| SCHEMBL29638405 | 0.85 | BTK (0.39) | TYK2POLBGAA | |
| SCHEMBL29638454 | 0.85 | TYK2 (0.41) | TYK2PIK3C3POLBGAA | |
| SCHEMBL24557315 | 0.85 | BTK (0.39) | TYK2POLBGAA | |
| SCHEMBL29638379 | 0.85 | TYK2 (0.41) | TYK2POLBGAAJAK2JAK1 | |
| SCHEMBL24557258 | 0.83 | NPC1 (0.41) | TYK2POLBGAA | |
| SCHEMBL29638464 | 0.83 | NPC1 (0.41) | TYK2POLBGAA | |
| SCHEMBL24557362 | 0.82 | TYK2 (0.48) | TYK2JAK2JAK1KCNH2 | |
| SCHEMBL29638386 | 0.82 | TYK2 (0.48) | TYK2JAK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |