Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736366 | 0.83 | PIK3C3 (0.53) | MEN1KMT2APIK3C3 | |
| SCHEMBL19728687 | 0.79 | RAB9A (0.40) | MEN1KMT2APIK3C3MAPTRAB9A | |
| SCHEMBL23015670 | 0.77 | KIF11 (0.42) | MEN1KMT2ANR3C2KIF11RAB9A | |
| SCHEMBL24542817 | 0.75 | AAK1 (0.40) | PIK3C3TRPV1 | |
| SCHEMBL6508707 | 0.72 | KMT2A (0.60) | MEN1KMT2AMAPK1MAPTRAB9A | |
| SCHEMBL2629423 | 0.71 | — | — | |
| SCHEMBL3415008 | 0.71 | PARP1 (0.38) | NNMTATM | |
| SCHEMBL20068995 | 0.71 | TDP1 (0.62) | KMT2AMAPTRAB9A | |
| SCHEMBL9749752 | 0.70 | NR3C2 (0.64) | MEN1KMT2ANR3C2MAPTRAB9A | |
| SCHEMBL17382220 | 0.68 | KIF11 (0.47) | KIF11MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |