Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | HTR3A | P46098 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | APEX1 | P27695 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.57 |
| ▸ | GABBR2 | O75899 | 6/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489425 | 1.00 | TAAR1 (0.64) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL3488185 | 1.00 | TAAR1 (0.64) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| Hydrochloric Acid SCHEMBL1570355 | 0.98 | APEX1 (0.65) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| Hydrochloric Acid SCHEMBL3573909 | 0.98 | APEX1 (0.65) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL4074768 | 0.87 | TAAR1 (0.80) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL15809806 | 0.82 | AOC3 (0.53) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL21199024 | 0.82 | AOC3 (0.53) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL21199026 | 0.82 | AOC3 (0.53) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| SCHEMBL7490714 | 0.81 | TAAR1 (0.64) | TAAR1TSHRNFKB1HTR3AHIF1A | |
| Hydrochloric Acid SCHEMBL21199119 | 0.80 | AOC3 (0.52) | TAAR1TSHRNFKB1HTR3AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2085235-A | — | — | None | — | — | JP | disclosed |
| US-12291535-B2 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | AGENEBIO, INC. (US) | 2025-05-06 | — | — | US | disclosed |
| CN-112601749-B | Benzodiazepine derivatives, compositions and methods for treating cognitive impairment | 艾吉因生物股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117178007-A | Phenylether oligomers and curable thermoset compositions comprising the same | 高新特殊工程塑料全球技术有限公司 | 2023-12-05 | — | — | CN | disclosed |
| EP-3743430-B1 | AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230107032-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-04-06 | — | — | US | disclosed |
| US-11414425-B2 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | AGENEBIO, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| CN-109734643-B | Method for synthesizing pyrroline compound by catalyzing amino alcohol and enol with iron | 陕西师范大学 | 2021-05-14 | — | — | CN | disclosed |
| CN-112601749-A | Benzodiazepine derivatives, compositions and methods for treating cognitive impairment | 艾吉因生物股份有限公司 | 2021-04-02 | — | — | CN | disclosed |
| US-20200048268-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-02-13 | — | — | US | disclosed |
| EP-0070133-A2 | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application | BEECHAM GROUP PLC (GB) | 1983-01-19 | — | — | EP | disclosed |
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| US-4309443-A | ANTI-OBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | disclosed |
| EP-0025331-A1 | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-03-18 | — | — | EP | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |
| US-4010191-A | Acyl derivatives of substituted bis-arylalkylamino compounds | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-03-01 | — | — | US | disclosed |
| US-3983133-A | CNS ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-09-28 | — | — | US | disclosed |
| US-3963718-A | CENTRAL NERVOUS SYSTEM ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA (BE) | 1976-06-15 | — | — | US | disclosed |
| US-3947456-A | ANTIDEPRESSANTS | HOFFMAN-LA ROCHE INC. (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230107032-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | GABRA5, GRM5, GABRA1 | TAAR1 163/4885TSHR 423/4885NFKB1 1741/4885 |
| US-11414425-B2 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | GABRA5, GRM5, GABRA1 | TAAR1 163/4885TSHR 423/4885NFKB1 1741/4885 |
| US-12291535-B2 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | GABRA5, GRM5, GABRA1 | TAAR1 163/4885TSHR 423/4885NFKB1 1741/4885 |
| US-20200048268-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | GABRA5, GRM5, GABRA1 | TAAR1 163/4885TSHR 423/4885NFKB1 1741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.