Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 6/20 | 0.34 |
| ▸ | NOTCH3 | Q9UM47 | 5/20 | 0.34 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22660114 | 0.91 | NOTCH1 (0.34) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL29640534 | 0.84 | NOTCH1 (0.33) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL12868885 | 0.76 | SLC1A3 (0.34) | — | |
| SCHEMBL12868892 | 0.76 | SLC1A3 (0.34) | — | |
| SCHEMBL12868893 | 0.76 | SLC1A3 (0.34) | — | |
| SCHEMBL4057289 | 0.72 | NOS2 (0.32) | — | |
| SCHEMBL24108958 | 0.70 | NOS2 (0.42) | — | |
| SCHEMBL1642298 | 0.70 | NOS2 (0.42) | — | |
| SCHEMBL1876375 | 0.70 | NOS2 (0.42) | — | |
| SCHEMBL3990465 | 0.69 | CA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969001-A1 | BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS FOR TREATING NOTCH-ACTIVATED BREAST CANCER | Ayala Pharmaceuticals Inc. (US) | 2022-03-23 | — | — | EP | claimed |