Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405574 | 0.90 | CA1 (0.31) | NOS2NOS3NOS1PSEN1PSEN2 | |
| SCHEMBL6065531 | 0.83 | — | — | |
| SCHEMBL5399204 | 0.81 | ODC1 (0.31) | — | |
| SCHEMBL22660114 | 0.79 | NOTCH1 (0.34) | NOS2NOS3NOS1HTTPSEN1 | |
| SCHEMBL27430163 | 0.78 | ENPEP (0.37) | NOS2NOS3NOS1HTT | |
| SCHEMBL24108958 | 0.77 | NOS2 (0.42) | NOS2NOS3NOS1HTT | |
| SCHEMBL1642298 | 0.77 | NOS2 (0.42) | NOS2NOS3NOS1HTT | |
| SCHEMBL27610140 | 0.77 | CA1 (0.37) | — | |
| SCHEMBL1876375 | 0.77 | NOS2 (0.42) | NOS2NOS3NOS1HTT | |
| SCHEMBL3917158 | 0.76 | HTT (0.32) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | claimed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | claimed |
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |