Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.54 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.48 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780551 | 1.00 | LMNA (0.65) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL6753157 | 0.91 | LMNA (0.55) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3003325 | 0.86 | LMNA (0.67) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3768764 | 0.86 | LMNA (0.82) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL10341233 | 0.86 | GABRA1 (0.53) | LMNAGABRA1GABRB2BAZ2BBAZ2A | |
| SCHEMBL2995302 | 0.85 | LMNA (0.66) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL6050608 | 0.85 | KMT2A (0.49) | LMNABAZ2BBAZ2AALDH1A1TDP1 | |
| SCHEMBL11524392 | 0.85 | LMNA (0.49) | LMNABAZ2BBAZ2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2998174 | 0.85 | MAP2K2 (0.52) | LMNABAZ2BBAZ2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6050613 | 0.85 | BAZ2B (0.54) | LMNABAZ2BBAZ2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641477-B | Compounds having inhibitory activity on glucosylceramide synthase or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| CN-114641477-A | Novel compound having inhibitory activity against glucose ceramide synthase or pharmaceutically acceptable salt thereof, method for preparing same, and pharmaceutical composition comprising same | 柳韩洋行 | 2022-06-17 | — | — | CN | disclosed |