Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23362197 | 1.00 | LMNA (0.48) | LMNACDK2MAP2K1KMT2AMEN1 | |
| SCHEMBL1096533 | 0.91 | CDK2 (0.49) | LMNACDK2MAP2K1KMT2AMEN1 | |
| SCHEMBL18589519 | 0.88 | LMNA (0.54) | LMNAMAP2K1KMT2AMEN1MCL1 | |
| SCHEMBL13798311 | 0.84 | LMNA (0.50) | LMNACDK2KMT2AMEN1KDM4E | |
| SCHEMBL11402828 | 0.83 | LMNA (0.49) | LMNAKMT2AMEN1KDM4ES1PR1 | |
| SCHEMBL3663507 | 0.82 | KMT2A (0.55) | LMNACDK2KMT2AMEN1MYC | |
| SCHEMBL28114450 | 0.82 | LMNA (0.40) | LMNAKMT2AMEN1MYCNR4A1 | |
| SCHEMBL23497662 | 0.81 | MYC (0.38) | LMNACDK2KMT2AMEN1MYC | |
| SCHEMBL29744413 | 0.81 | MYC (0.38) | LMNACDK2KMT2AMEN1MYC | |
| SCHEMBL5780551 | 0.81 | LMNA (0.65) | LMNACDK2KMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641477-B | Compounds having inhibitory activity on glucosylceramide synthase or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| CN-114641477-A | Novel compound having inhibitory activity against glucose ceramide synthase or pharmaceutically acceptable salt thereof, method for preparing same, and pharmaceutical composition comprising same | 柳韩洋行 | 2022-06-17 | — | — | CN | disclosed |