Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 4/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22234902 | 1.00 | CDK1 (0.45) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22835096 | 0.83 | CCNA2 (0.50) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22835095 | 0.83 | CCNA2 (0.50) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22842992 | 0.79 | NUDT1 (0.54) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL1180511 | 0.79 | NUDT1 (0.44) | CCNA2CDK2CCNA1NUDT1P2RX3 | |
| SCHEMBL15585186 | 0.78 | KDM4E (0.33) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL29598152 | 0.78 | CDK1 (0.45) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22234790 | 0.78 | CDK1 (0.45) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL22234796 | 0.76 | NUDT1 (0.46) | NUDT1DHFR | |
| SCHEMBL22835056 | 0.73 | P2RX3 (0.42) | CDK1CCNB1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140425-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE | BIOGEN MA INC. (US) | 2022-06-30 | — | — | WO | disclosed |