Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29640916 | 0.72 | SMN1; SMN2 (0.41) | GSK3B | |
| SCHEMBL29640865 | 0.71 | GSK3B (0.36) | GSK3BCDC7P2RX7GRM5 | |
| SCHEMBL10402322 | 0.68 | HSP90AA1 (0.48) | GSK3BCDC7CCNT1CCNA2CDK2 | |
| SCHEMBL2814353 | 0.67 | HSP90AA1 (0.52) | GSK3BCDC7CCNT1CCNA2CDK2 | |
| SCHEMBL30595872 | 0.67 | HSP90AA1 (0.52) | GSK3BCDC7CCNT1CCNA2CDK2 | |
| SCHEMBL4759558 | 0.66 | GSK3B (0.55) | GSK3B | |
| SCHEMBL13910999 | 0.65 | HSP90AA1 (0.50) | GSK3BCDC7CCNT1CCNA2CDK2 | |
| SCHEMBL173216 | 0.62 | GSK3B (0.61) | GSK3B | |
| SCHEMBL9903935 | 0.61 | CYP2D6 (0.60) | GSK3BGRM5MAP4K4EGFRFRK | |
| SCHEMBL10841550 | 0.61 | DYRK1A (0.57) | GSK3BMAP4K4EGFRFRKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209658-A | Inhibitors of RHO-associated coiled coil kinase | 安吉昂生物医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-114502163-A | Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2022-05-13 | — | — | CN | disclosed |