SCHEMBL29640795

SCHEMBL29640795

COc1ccc2c(c1)CN(c1nccc(-c3nccc(C#Cc4ccccc4C#N)n3)n1)C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 8/20 0.42
ROCK1 Q13464 4/20 0.42
PDE10A Q9Y233 2/20 0.37
ALDH1A1 P00352 3/20 0.36
MAPT P10636 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 2/20 0.35
HPGD P15428 1/20 0.35
PTBP1 P26599 1/20 0.35
MEN1 O00255 2/20 0.34
ALOX15 P16050 2/20 0.34
MAPK1 P28482 2/20 0.34
CASP1 P29466 2/20 0.34
CASP7 P55210 2/20 0.34
KMT2A Q03164 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
RUNX1 Q01196 1/20 0.34
CBFB Q13951 1/20 0.34
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29640451 0.87 ROCK2 (0.44) ROCK2ROCK1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL29640901 0.86 HCRTR1 (0.41) ROCK2ROCK1PDE10AALDH1A1KDM4E
SCHEMBL29640913 0.85 ROCK2 (0.42) ROCK2ROCK1MAPTHCRTR1HCRTR2
SCHEMBL29640909 0.84 SCN9A (0.42) ROCK2ROCK1HCRTR1HCRTR2
SCHEMBL29627935 0.83 ROCK2 (0.52) ROCK2ROCK1PDE10AHCRTR1HCRTR2
SCHEMBL29640758 0.82 ROCK2 (0.41) ROCK2ROCK1PDE10AHCRTR1HCRTR2
SCHEMBL29627937 0.82 ROCK2 (0.54) ROCK2ROCK1
SCHEMBL29640938 0.80 ROCK2 (0.42) ROCK2ROCK1PDE10AHCRTR1HCRTR2
SCHEMBL29627955 0.80 ROCK2 (0.42) ROCK2ROCK1KDM4EHCRTR1HCRTR2
SCHEMBL20769697 0.79 ROCK2 (0.55) ROCK2ROCK1ALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114502163-A Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors 安吉昂生物医药公司 2022-05-13 CN disclosed