Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22504992 | 1.00 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL29641495 | 0.88 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL22504987 | 0.88 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL16783614 | 0.82 | TP53 (0.45) | ALDH1A1SMN1; SMN2LMNAL3MBTL1TP53 | |
| SCHEMBL16783421 | 0.81 | MEN1 (0.45) | ALDH1A1DRD2ACHETLR8TLR7 | |
| SCHEMBL16783613 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL22498062 | 0.80 | ACHE (0.52) | ALDH1A1SMN1; SMN2LMNATP53ACHE | |
| SCHEMBL30679717 | 0.80 | ACHE (0.52) | ALDH1A1SMN1; SMN2LMNATP53ACHE | |
| SCHEMBL16783528 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNANPSR1L3MBTL1 | |
| SCHEMBL16783749 | 0.79 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12527797-B2 | Isochromene derivatives as phosphoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-01-20 | — | — | US | disclosed |
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | PIKFYVE, PDPK1, PIK3R5 | ALDH1A1 3562/4885SMN1; SMN2 2951/4885LMNA 4307/4885 |
| US-12527797-B2 | Isochromene derivatives as phosphoinositide 3-kinases inhibitors | PIK3R5, PIK3CD, PIK3R4 | ALDH1A1 3567/4885SMN1; SMN2 4264/4885LMNA 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.