Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 8/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151829 | 0.84 | PIK3CD (0.55) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL4965296 | 0.77 | PIK3CD (0.52) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL8036551 | 0.76 | PIK3CD (0.51) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL28739251 | 0.74 | PIK3CD (0.42) | PIK3CDPIK3CAPIM1PIM2KDM4E | |
| SCHEMBL10284715 | 0.74 | MAP4K4 (0.43) | PIK3CDPIK3CAKDM4ENPC1RAB9A | |
| SCHEMBL12615927 | 0.74 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL1509667 | 0.74 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL12696158 | 0.74 | PIK3CD (0.36) | PIK3CDPIK3CAPIM1PIM2PIM3 | |
| SCHEMBL2036795 | 0.74 | ADORA2A (0.45) | KDM4EALDH1A1ADORA2AADORA1 | |
| SCHEMBL2367393 | 0.74 | KDM4E (0.44) | KDM4ETDP1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4007578-A4 | SUBSTITUTED CYCLOPROPYL-2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-08-16 | — | — | EP | disclosed |
| EP-4007578-A1 | SUBSTITUTED CYCLOPROPYL-2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma, Inc. (US) | 2022-06-08 | — | — | EP | disclosed |