Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036551 | 0.95 | PIK3CD (0.51) | PIK3CDPIK3CAUSP30PIM1PIM3 | |
| SCHEMBL1151829 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CAUSP30PIM1PIM3 | |
| SCHEMBL13294661 | 0.85 | HPGDS (0.51) | PIK3CDPIK3CAUSP30PIM1PIM3 | |
| SCHEMBL29641671 | 0.77 | PIK3CD (0.49) | PIK3CDPIK3CAUSP30PIM1PIM3 | |
| SCHEMBL4879777 | 0.77 | PIK3CD (0.42) | PIK3CDPIK3CAUSP30 | |
| SCHEMBL28404203 | 0.74 | ADORA1 (0.54) | PIK3CAUSP30NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL190954 | 0.73 | AURKA (0.63) | MAPTKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL29620532 | 0.73 | AURKA (0.63) | MAPTKMT2AKDM4EMEN1NPC1 | |
| Ammonia Solution, Strong SCHEMBL20267253 | 0.71 | AURKA (0.61) | MAPTKMT2AKDM4EMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL8889589 | 0.71 | KMT2A (0.40) | PIK3CDPIK3CAUSP30PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888523-A2 | CYCLOBUTYL AMINE DERIVATIVES | Abbott Laboratories (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006132914-A2 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2006-12-14 | — | — | WO | claimed |
| EP-1888523-A2 | CYCLOBUTYL AMINE DERIVATIVES | Abbott Laboratories (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006132914-A2 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2006-12-14 | — | — | WO | disclosed |