Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amlexanox. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 1.00 |
| ▸ | TBK1 | Q9UHD2 | 20/20 | 1.00 |
| ▸ | IKBKE | Q14164 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | TTR | P02766 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amlexanox SCHEMBL29381739 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL5058549 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29441547 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2907023 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2908304 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2902814 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL16216144 | 0.93 | TBK1 (0.87) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19180152 | 0.91 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL16216162 | 0.90 | TBK1 (0.82) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19197522 | 0.90 | TBK1 (0.81) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4809 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124274-A1 | METHODS OF INCREASING READTHROUGH OF A PREMATURE TERMINATION CODON | UNIV RAMOT (IL) | 2026-05-07 | — | — | US | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087695-A1 | TREATMENT FOR METABOLIC DISORDER | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| EP-3991729-B1 | USE OF AMLEXANOX IN PREPARING ANTI-HEPATITIS VIRUS DRUG | MARINE BIOMEDICAL RES INST QINGDAO CO LTD (CN) | 2026-03-25 | — | — | EP | claimed |
| US-20260023070-A1 | OPTOGENETIC ALPHA-SYNUCLEIN AGGREGATION SYSTEM-BASED COMPOUND SCREENING PLATFORM IN PD-hiPSC-mDA NEURONS | UNIV JOHNS HOPKINS (US) | 2026-01-22 | — | — | US | claimed |
| EP-4682248-A1 | NEW HUMAN TISSUE ORGANOID CULTURE SYSTEM | Peking University (CN) | 2026-01-21 | — | — | EP | claimed |
| EP-4665334-A1 | TRIPLE KINASE INHIBITION FOR THE TREATMENT OF TYPE I INTERFERON RESPONSE ASSOCIATED DISORDERS | Universität zu Köln (DE) | 2025-12-24 | — | — | EP | claimed |
| US-20250313862-A1 | INHIBITION OF GENOTOXIC STRESS TO IMPROVE T CELL ENGINEERING | GENENTECH INC (US) | 2025-10-09 | — | — | US | claimed |
| EP-4622711-A1 | TREATMENT OF TARTARIC ACID TOXICITY IN DOGS WITH PROBENECID | MCPHS University (US) | 2025-10-01 | — | — | EP | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-5362737-A | Determined by reduction of ulcer size; topical administering in vehicle | CHEMEX PHARMACEUTICALS, INC. (US) | 1994-11-08 | — | — | US | claimed |
| EP-0484529-B1 | SKIN CREAM PREPARATION FOR EXTERNAL USE | HISAMITSU PHARMACEUTICAL CO (JP) | 1994-04-27 | — | — | EP | claimed |
| WO-1993024918-A1 | A MUSIC LEARNING AID | HESNAN JOHN (IE) | 1993-12-09 | — | — | WO | claimed |
| US-5227372-A | METHOD FOR RETAINING OPHTHALMOLOGICAL AGENTS IN OCULAR TISSUES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1993-07-13 | — | — | US | claimed |
| EP-0475536-A1 | Spherical granules having core and their production | Takeda Chemical Industries, Ltd. (JP) | 1992-03-18 | — | — | EP | claimed |
| EP-0213514-B1 | AQUEOUS LIQUID PREPARATION | Takeda Chemical Industries, Ltd. (JP) | 1990-06-20 | — | — | EP | claimed |
| EP-0277741-A1 | Spherical granules having core and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-08-10 | — | — | EP | claimed |
| US-4728509-A | NOSE OR EYE DROPS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-01 | — | — | US | claimed |
| EP-0213514-A2 | Aqueous liquid preparation | Takeda Chemical Industries, Ltd. (JP) | 1987-03-11 | — | — | EP | claimed |
| US-4143042-A | ANTIALLERGENS, BRONCHODILATOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1979-03-06 | — | — | US | claimed |