Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amlexanox. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 1.00 |
| ▸ | TBK1 | Q9UHD2 | 20/20 | 1.00 |
| ▸ | IKBKE | Q14164 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | TTR | P02766 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amlexanox SCHEMBL29381739 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29441547 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29642 | 1.00 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2907023 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2908304 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL2902814 | 0.99 | TBK1 (0.98) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL16216144 | 0.93 | TBK1 (0.87) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19180152 | 0.91 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL16216162 | 0.90 | TBK1 (0.82) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19197522 | 0.90 | TBK1 (0.81) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-2892518-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037416-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |
| EP-1931760-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | The University of Alabama (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044693-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | THE UNIVERSITY OF ALABAMA (US) | 2007-04-19 | — | — | WO | disclosed |