Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28451638 | 1.00 | L3MBTL1 (0.49) | L3MBTL1PTGS2PTGS1HPGDLMNA | |
| SCHEMBL28447862 | 0.88 | CHEK1 (0.44) | L3MBTL1HPGDNPSR1ALOX5APFEN1 | |
| SCHEMBL29642634 | 0.88 | ACACA (0.46) | L3MBTL1HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL28452953 | 0.88 | ACACA (0.46) | L3MBTL1HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL28448880 | 0.86 | KIT (0.45) | L3MBTL1PDGFRBPDGFRAGSK3AGSK3B | |
| SCHEMBL29642725 | 0.86 | KIT (0.45) | L3MBTL1PDGFRBPDGFRAGSK3AGSK3B | |
| SCHEMBL28452528 | 0.86 | PIM1 (0.44) | L3MBTL1HPGDNPSR1NFKB1SMN1; SMN2 | |
| SCHEMBL29642685 | 0.85 | CHEK1 (0.40) | L3MBTL1HPGDNPSR1SMN1; SMN2PDGFRA | |
| SCHEMBL28448920 | 0.84 | CHEK1 (0.45) | LMNAMAPK1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL28450068 | 0.84 | MEN1 (0.56) | L3MBTL1HPGDLMNASMN1; SMN2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111205236-B | Naphthalene ring-isoxazole type compound and preparation method and application thereof | 贵州医科大学 | 2022-07-01 | — | — | CN | disclosed |