Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890014 | 1.00 | AXL (0.55) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL1663211 | 0.79 | AXL (0.60) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL29643873 | 0.77 | NTRK1 (0.56) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL22445971 | 0.77 | NTRK1 (0.56) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL4008208 | 0.76 | DCLK1 (0.65) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL12193658 | 0.76 | MKNK1 (0.61) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL31423230 | 0.76 | DCLK1 (0.65) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL12193885 | 0.75 | AXL (0.57) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL2469031 | 0.73 | AXL (0.55) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL4006856 | 0.73 | AXL (0.55) | AXLHTR2AHTR2CHTR2BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |