Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.51 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26980085 | 1.00 | TRPA1 (0.51) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL3537177 | 0.78 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| SCHEMBL29935743 | 0.78 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| SCHEMBL12515210 | 0.77 | TRPA1 (0.52) | TRPA1GSK3BSCN5AKIF11METAP2 | |
| SCHEMBL2662677 | 0.76 | TRPA1 (0.56) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL3538242 | 0.76 | TTK (0.54) | KIF11 | |
| SCHEMBL29497531 | 0.75 | PDPK1 (0.58) | GSK3BMETAP2 | |
| SCHEMBL15304355 | 0.75 | ITK (0.46) | MAP2K4MAPK1MAPK6MAPKAPK5KIF11 | |
| SCHEMBL29955085 | 0.75 | ITK (0.46) | MAP2K4MAPK1MAPK6MAPKAPK5KIF11 | |
| SCHEMBL5211222 | 0.75 | MAP2K4 (0.48) | TRPA1MAP2K4GSK3BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867768-A | STING antagonists and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2023-10-10 | — | — | CN | disclosed |
| EP-4247790-A1 | STING ANTAGONISTS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022105930-A1 | STING ANTAGONISTS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2022-05-27 | — | — | WO | disclosed |