Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26979848 | 1.00 | KDM4E (0.48) | KDM4ESTAT3HIF1AGSK3BMAP2K4 | |
| SCHEMBL492421 | 0.86 | GSK3B (0.50) | GSK3BIKBKETBK1 | |
| SCHEMBL2856720 | 0.79 | GSK3B (0.46) | KDM4EGSK3BIDH1PAK1 | |
| SCHEMBL13528913 | 0.79 | GSK3B (0.46) | KDM4EGSK3BIDH1PAK1 | |
| SCHEMBL2088884 | 0.78 | DYRK1A (0.56) | GSK3BPAK1 | |
| SCHEMBL1572799 | 0.77 | GSK3B (0.59) | GSK3BIKBKETBK1JAK2 | |
| SCHEMBL1176284 | 0.76 | GSK3B (0.45) | GSK3BIDH1PAK1SCN9AIKBKE | |
| SCHEMBL5043690 | 0.76 | GSK3B (0.45) | GSK3BIDH1PAK1SCN9AIKBKE | |
| Formic Acid SCHEMBL2854182 | 0.76 | GSK3B (0.43) | KDM4EGSK3BIDH1PAK1 | |
| SCHEMBL2088724 | 0.76 | GSK3B (0.49) | GSK3BPAK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867768-A | STING antagonists and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2023-10-10 | — | — | CN | disclosed |
| EP-4247790-A1 | STING ANTAGONISTS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022105930-A1 | STING ANTAGONISTS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2022-05-27 | — | — | WO | disclosed |