Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176284 | 1.00 | GSK3B (0.45) | GSK3BJAK2JAK1TYK2JAK3 | |
| Formic Acid SCHEMBL5562317 | 0.97 | GSK3B (0.43) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL1176422 | 0.93 | GSK3B (0.53) | GSK3BDYRK1AWNT1 | |
| SCHEMBL5043498 | 0.93 | GSK3B (0.53) | GSK3BDYRK1AWNT1 | |
| Formic Acid SCHEMBL5556898 | 0.90 | GSK3B (0.50) | GSK3BDYRK1AWNT1 | |
| SCHEMBL14391094 | 0.82 | GSK3B (0.47) | GSK3BUSP30IDH1BRD4PAK1 | |
| SCHEMBL2088724 | 0.81 | GSK3B (0.49) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL5048250 | 0.80 | GSK3B (0.48) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL1176818 | 0.80 | GSK3B (0.48) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL5044511 | 0.80 | CDK2 (0.48) | GSK3BJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |