Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | ITGAL | P20701 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28739188 | 1.00 | LMNA (0.50) | LMNAHPGDMAPTKMT2ACA1 | |
| SCHEMBL28739096 | 0.93 | LMNA (0.49) | LMNAHPGDMAPTKMT2ACA1 | |
| SCHEMBL29644389 | 0.93 | LMNA (0.49) | LMNAHPGDMAPTKMT2ACA1 | |
| SCHEMBL28739066 | 0.87 | FFAR1 (0.44) | LMNAHPGDMAPTKMT2APRMT5 | |
| SCHEMBL29644332 | 0.87 | FFAR1 (0.44) | LMNAHPGDMAPTKMT2APRMT5 | |
| SCHEMBL28739082 | 0.86 | FFAR1 (0.51) | LMNAHPGDMAPTKMT2ACA1 | |
| SCHEMBL29644457 | 0.86 | FFAR1 (0.51) | LMNAHPGDMAPTKMT2ACA1 | |
| SCHEMBL28739056 | 0.86 | MAPK1 (0.46) | LMNAHPGDMAPTKMT2APRMT5 | |
| SCHEMBL29644412 | 0.86 | MAPK1 (0.46) | LMNAHPGDMAPTKMT2APRMT5 | |
| SCHEMBL28739159 | 0.83 | FFAR1 (0.50) | LMNAHPGDMAPTKMT2APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507181-B | Propionic acid compound containing 5-substituted tetrahydroisoquinoline, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-03-26 | — | — | CN | disclosed |
| CN-114507181-A | Propionic acid compound containing 5-substituted tetrahydroisoquinoline, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | disclosed |