Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18728167 | 1.00 | HTR7 (0.43) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL26636424 | 0.95 | HTR7 (0.42) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL26636905 | 0.91 | HTR7 (0.44) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL22807537 | 0.90 | MAPT (0.39) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| Bicarbonate SCHEMBL29992844 | 0.89 | SMN1; SMN2 (0.39) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL18728445 | 0.85 | HTR7 (0.43) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL29772127 | 0.85 | HTR7 (0.43) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL28751083 | 0.85 | CYP1A2 (0.50) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL30504433 | 0.84 | HTR1B (0.50) | HTR7MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL18757446 | 0.84 | HTR1B (0.50) | HTR7MAPTL3MBTL1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519259-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| EP-4519260-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XDEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| CN-112566900-B | Immunomodulator, composition and preparation method thereof | 贝达药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117561246-A | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| WO-2023215471-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023215482-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |
| CN-111793077-B | PD-1/PD-L1 small molecule inhibitor and application thereof in medicines | 东莞市东阳光新药研发有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-111788193-B | PD-1/PD-L1 small molecule inhibitor and application thereof in medicines | 广东东阳光药业有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-109863146-B | Biaryl compounds as immunomodulators | 百时美施贵宝公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-113461668-B | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| EP-3759093-B1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-30 | — | — | EP | disclosed |
| EP-4037776-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114761085-A | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110128415-B | Indoline compound used as immunomodulator and preparation method thereof | 沈阳药科大学 | 2022-03-25 | — | — | CN | disclosed |