Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648252 | 0.89 | HTR7 (0.43) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL18728167 | 0.89 | HTR7 (0.43) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL26636424 | 0.84 | HTR7 (0.42) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL26636905 | 0.81 | HTR7 (0.44) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL22807537 | 0.80 | MAPT (0.39) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL26639498 | 0.78 | PPARG (0.49) | SMN1; SMN2MEN1KMT2APPARGPPARD | |
| SCHEMBL30734673 | 0.77 | PPARG (0.51) | SMN1; SMN2MEN1KMT2APPARGPPARA | |
| SCHEMBL26635776 | 0.77 | CYP4F2 (0.45) | PPARGALDH1A1TDP1 | |
| SCHEMBL30734588 | 0.77 | CYP4F2 (0.45) | PPARGALDH1A1TDP1 | |
| SCHEMBL26639555 | 0.77 | PPARG (0.51) | SMN1; SMN2MEN1KMT2APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4037776-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2022-08-10 | — | — | EP | disclosed |