Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.49 |
| ▸ | JAK1 | P23458 | 10/20 | 0.49 |
| ▸ | TYK2 | P29597 | 7/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495070 | 1.00 | JAK2 (0.49) | JAK2JAK1TYK2JAK3SCN10A | |
| SCHEMBL29648482 | 0.92 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23495066 | 0.92 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23495076 | 0.90 | JAK2 (0.44) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL23495071 | 0.87 | JAK2 (0.49) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL23495092 | 0.82 | JAK2 (0.51) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23495059 | 0.79 | JAK2 (0.60) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL941554 | 0.76 | JAK2 (0.76) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL23495050 | 0.75 | JAK2 (0.61) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL23495079 | 0.73 | ALDH1A1 (0.40) | JAK2JAK1TYK2JAK3SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110494434-B | Pyrazolophenyl compounds, compositions thereof, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-05-24 | — | — | CN | disclosed |