Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21601775 | 1.00 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 | |
| SCHEMBL7258173 | 0.89 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 | |
| SCHEMBL16363087 | 0.89 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 | |
| SCHEMBL16363076 | 0.89 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 | |
| Hydrochloric Acid SCHEMBL28304616 | 0.87 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 | |
| SCHEMBL15386162 | 0.84 | IDO1 (0.43) | CHRNB2CHRNA4CHRNA7FDPSIDO1 | |
| SCHEMBL18816531 | 0.84 | IDO1 (0.43) | CHRNB2CHRNA4CHRNA7FDPSIDO1 | |
| SCHEMBL30251479 | 0.84 | IDO1 (0.43) | CHRNB2CHRNA4CHRNA7FDPSIDO1 | |
| SCHEMBL17545496 | 0.79 | — | — | |
| SCHEMBL18795036 | 0.76 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA7FDPSCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306635-A1 | TDO2 Inhibitors | GENENTECH, INC. | 2022-09-29 | — | — | US | disclosed |
| CN-110072864-B | TDO2 inhibitors | 基因泰克公司 | 2022-05-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306635-A1 | TDO2 Inhibitors | TDO2, IDO2, IDO1 | CHRNB2 2272/4885CHRNA4 4169/4885CHRNA7 3586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.