Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 5/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 3/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935850 | 0.90 | DPP4 (0.48) | DPP4DPP8PARP1PARP2PARP3 | |
| SCHEMBL29649972 | 0.83 | CYP8B1 (0.48) | DPP4DPP8P2RX7CYP8B1 | |
| SCHEMBL29650119 | 0.80 | CYP8B1 (0.49) | DPP4DPP8P2RX7DPP7CYP8B1 | |
| SCHEMBL5231477 | 0.79 | TACR3 (0.46) | DPP4DPP8PARP1PARP2PARP3 | |
| SCHEMBL3868870 | 0.73 | TACR3 (0.39) | DPP4DPP8PARP1PARP2PARP3 | |
| SCHEMBL5648690 | 0.72 | P2RX7 (0.38) | DPP4DPP8P2RX7DPP7CYP8B1 | |
| SCHEMBL5935844 | 0.71 | DPP4 (0.49) | DPP4DPP8PARP1P2RX7TACR1 | |
| SCHEMBL16790052 | 0.70 | DPP4 (0.32) | DPP4DPP8DPP7 | |
| SCHEMBL3842976 | 0.68 | DPP4 (0.47) | DPP4DPP8PARP1PARP2PARP3 | |
| SCHEMBL16789995 | 0.68 | DPP4 (0.41) | DPP4DPP8PARP1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255900-A2 | ENZYME INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118016-A2 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-06-09 | — | — | WO | disclosed |