Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 13/20 | 0.61 |
| ▸ | LATS2 | Q9NRM7 | 10/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29650587 | 0.83 | LATS1 (0.56) | LATS1LATS2EGFRGALR3NR2F2 | |
| SCHEMBL31375142 | 0.78 | GALR3 (0.58) | LATS1LATS2EGFRGALR3NR2F2 | |
| SCHEMBL20573808 | 0.76 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL29650608 | 0.75 | LATS1 (0.60) | LATS1LATS2EGFR | |
| SCHEMBL22302812 | 0.74 | LATS1 (0.56) | LATS1LATS2EGFRCD38LMNA | |
| SCHEMBL3322882 | 0.72 | EGFR (0.56) | LATS1LATS2EGFRLMNAHTT | |
| SCHEMBL31375768 | 0.69 | EGFR (0.65) | LATS1EGFRCD38LMNA | |
| SCHEMBL29650589 | 0.69 | EGFR (0.61) | LATS1LATS2EGFRLMNAHTT | |
| SCHEMBL6371635 | 0.68 | EGFR (0.42) | LATS1LATS2EGFR | |
| SCHEMBL3327457 | 0.68 | EGFR (0.52) | LATS1LATS2EGFRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |