Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 16/20 | 0.60 |
| ▸ | LATS2 | Q9NRM7 | 13/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22302812 | 0.84 | LATS1 (0.56) | LATS1LATS2EGFRCYP1A2 | |
| SCHEMBL29650600 | 0.75 | LATS1 (0.61) | LATS1LATS2EGFR | |
| SCHEMBL20574756 | 0.75 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL31375768 | 0.73 | EGFR (0.65) | LATS1EGFRCYP1A2 | |
| SCHEMBL3322882 | 0.73 | EGFR (0.56) | LATS1LATS2EGFR | |
| SCHEMBL20574249 | 0.72 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL26177166 | 0.72 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL29650587 | 0.72 | LATS1 (0.56) | LATS1LATS2EGFR | |
| SCHEMBL31375184 | 0.72 | EGFR (0.53) | LATS1EGFR | |
| SCHEMBL20547766 | 0.71 | LATS1 (1.00) | LATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | claimed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |