Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22864566 | 1.00 | HTR6 (0.60) | HTR6LMNASMN1; SMN2PLK1CA12 | |
| SCHEMBL27152273 | 0.88 | KDM4E (0.64) | HTR6LMNASMN1; SMN2CA2CA9 | |
| SCHEMBL29651324 | 0.84 | CA12 (0.63) | HTR6LMNASMN1; SMN2PLK1CA12 | |
| SCHEMBL22864562 | 0.84 | CA12 (0.63) | HTR6LMNASMN1; SMN2PLK1CA12 | |
| SCHEMBL14207893 | 0.84 | HTR6 (0.60) | HTR6LMNASMN1; SMN2PLK1CA12 | |
| SCHEMBL29365123 | 0.84 | HTR6 (0.55) | HTR6LMNASMN1; SMN2HTR1ACYP3A4 | |
| SCHEMBL20354867 | 0.84 | HTR6 (0.55) | HTR6LMNASMN1; SMN2HTR1ACYP3A4 | |
| SCHEMBL29365118 | 0.84 | HTR6 (0.55) | HTR6LMNASMN1; SMN2HTR1ACYP3A4 | |
| SCHEMBL30991290 | 0.83 | L3MBTL1 (0.47) | HTR6LMNASMN1; SMN2PLK1MEN1 | |
| SCHEMBL21596675 | 0.83 | L3MBTL1 (0.47) | HTR6LMNASMN1; SMN2PLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |