Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29651982 | 0.94 | KDM4E (0.46) | KDM4EALDH1A1HPGDPDE5APOLB | |
| SCHEMBL24983895 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HPGDPDE5APOLB | |
| SCHEMBL16373611 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1HPGDPDE5APOLB | |
| SCHEMBL12196880 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDPOLBRAB9A | |
| SCHEMBL29651995 | 0.75 | — | — | |
| SCHEMBL20653275 | 0.75 | NPC1 (0.43) | KDM4EALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL19514979 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1HPGDPDE5APOLB | |
| SCHEMBL21186362 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1HPGDPDE5ARAB9A | |
| SCHEMBL17788455 | 0.74 | TP53 (0.42) | KDM4EALDH1A1HPGDPDE5APOLB | |
| SCHEMBL22276485 | 0.72 | KDM4E (0.52) | KDM4EALDH1A1HPGDPDE5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867781-A | Imidazo [1,2-a ] pyridine derivatives as IRAK4 inhibitors and their use in the treatment of diseases | 渤健马萨诸塞州股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-114245796-A | Imidazo [1,2-a ] pyridinyl derivatives and their use in the treatment of disease | 比奥根MA公司 | 2022-03-25 | — | — | CN | disclosed |