Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.52 |
| ▸ | HPGD | P15428 | 10/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19514979 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL24983895 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL12196880 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL29651982 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL16373611 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL29651998 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL23553677 | 0.72 | PDE2A (0.31) | — | |
| SCHEMBL22337396 | 0.70 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL17788455 | 0.70 | TP53 (0.42) | KDM4EALDH1A1HPGDPDE5ANPC1 | |
| SCHEMBL15038291 | 0.70 | SMN1; SMN2 (0.40) | KDM4EALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200239435-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | ATTUNE PHARMACEUTICALS, INC. | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239435-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | KLKB1, SERPINB1, SERPINE1 | KDM4E 798/4885ALDH1A1 1717/4885HPGD 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.