Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455990 | 1.00 | BACE1 (0.56) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL17300476 | 0.83 | BACE1 (0.56) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| Water SCHEMBL6574638 | 0.80 | L3MBTL1 (0.60) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1014901 | 0.79 | BACE1 (0.63) | BACE1EGFRMAPTALDH1A1NPSR1 | |
| SCHEMBL29953102 | 0.79 | BACE1 (0.63) | BACE1EGFRMAPTALDH1A1NPSR1 | |
| SCHEMBL7750354 | 0.78 | MAPT (0.56) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7750350 | 0.78 | MAPT (0.56) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL6562672 | 0.77 | BACE1 (0.61) | BACE1EGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL10831447 | 0.77 | BACE1 (0.61) | BACE1EGFRMAPTALDH1A1NPSR1 | |
| Water SCHEMBL6574634 | 0.77 | MAPT (0.55) | BACE1EGFRMAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |