Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2970151 | 0.85 | NR1H2 (0.41) | NAMPTNR1H2MAPTPREPMAPK1 | |
| SCHEMBL8214051 | 0.84 | NR1H2 (0.40) | NAMPTNR1H2MAPTPREPMAPK1 | |
| SCHEMBL8213557 | 0.82 | NAMPT (0.35) | NAMPTNR1H2PREPMAPK1ALDH1A1 | |
| SCHEMBL8220942 | 0.81 | NAMPT (0.34) | NAMPTNR1H2PREPMAPK1ALDH1A1 | |
| SCHEMBL23794838 | 0.80 | NR1H2 (0.43) | NAMPTNR1H2MAPTPREPMAPK1 | |
| SCHEMBL13221366 | 0.79 | ALDH1A1 (0.38) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2982986 | 0.78 | NAMPT (0.33) | NAMPTNR1H2PREPTAOK3 | |
| SCHEMBL1224464 | 0.77 | MAPT (0.48) | NAMPTNR1H2MAPTPREPALDH1A1 | |
| SCHEMBL1224468 | 0.77 | MAPT (0.48) | NAMPTNR1H2MAPTPREPALDH1A1 | |
| SCHEMBL30456334 | 0.77 | MAPT (0.48) | NAMPTNR1H2MAPTPREPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781474-B2 | Inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781474-B2 | Inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781474-B2 | Inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100209391-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-08-19 | — | — | US | disclosed |
| US-20100209391-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-08-19 | — | — | US | disclosed |
| US-20100209391-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-08-19 | — | — | US | disclosed |
| US-20080019942-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080019942-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080019942-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100209391-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HDGF | NAMPT 1834/4885NR1H2 323/4885MAPT 4374/4885 |
| US-20080019942-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, GTF3C3 | NAMPT 2134/4885NR1H2 469/4885MAPT 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.