Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982740 | 1.00 | NPC1 (0.59) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL30849526 | 0.93 | ALDH1A1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL28905508 | 0.90 | MAPT (0.52) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL21070371 | 0.89 | NPC1 (0.51) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL29612659 | 0.89 | NPC1 (0.51) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL30163655 | 0.88 | NPC1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2062578 | 0.87 | NPC1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2061925 | 0.86 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL19058464 | 0.84 | NQO2 (0.46) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL22121203 | 0.84 | KMT2A (0.47) | NPC1RAB9AMAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4710923-A2 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2026-03-18 | — | — | EP | disclosed |
| EP-3612030-B1 | INDOLE AHR INHIBITORS AND USES THEREOF | IKENA ONCOLOGY INC (US) | 2025-12-24 | — | — | EP | disclosed |
| US-20250122205-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2025-04-17 | — | — | US | disclosed |
| US-12077542-B2 | Indole AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2024-09-03 | — | — | US | disclosed |
| CN-118119598-A | Medicine for treating human tumor by eRF3a targeting protein degradation mechanism | 苏州德亘生物医药有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117801051-A | Medicine for treating human tumor by eRF3a targeting protein degradation mechanism | 苏州德亘生物医药有限公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-11358969-B2 | Indole AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2022-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358969-B2 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | NPC1 2267/4885RAB9A 4560/4885MAPT 4171/4885 |
| US-20250122205-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | NPC1 2267/4885RAB9A 4560/4885MAPT 4171/4885 |
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | NPC1 2267/4885RAB9A 4560/4885MAPT 4171/4885 |
| US-12077542-B2 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | NPC1 2267/4885RAB9A 4560/4885MAPT 4171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.