Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655785 | 0.84 | CYP26A1 (0.46) | PTGER4CYP26A1CYP26B1NPC1RAB9A | |
| SCHEMBL29655732 | 0.79 | NPC1 (0.62) | PTGER4NPC1RAB9AHPGDTP53 | |
| SCHEMBL29696137 | 0.76 | CYP26A1 (0.47) | PTGER4CYP26A1CYP26B1NPC1RAB9A | |
| SCHEMBL29655794 | 0.75 | MAPK14 (0.45) | CYP26A1CYP26B1RAB9AHPGDKDM4E | |
| SCHEMBL8454439 | 0.75 | TAS1R3 (0.67) | NPC1RAB9AKLF5HPGDTP53 | |
| SCHEMBL10559161 | 0.74 | RARB (0.70) | CYP26A1CYP26B1NPC1RAB9APTGS1 | |
| SCHEMBL10559147 | 0.74 | RARB (0.70) | CYP26A1CYP26B1NPC1RAB9APTGS1 | |
| SCHEMBL29655711 | 0.74 | SMN1; SMN2 (0.52) | CYP26A1CYP26B1NPC1RAB9AHPGD | |
| SCHEMBL29655733 | 0.74 | PLK1 (0.42) | PTGER4CYP26A1CYP26B1NPC1RAB9A | |
| SCHEMBL29655774 | 0.73 | NPC1 (0.56) | PTGER4NPC1RAB9AHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138793-A1 | COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST | 小野薬品工業株式会社 | 2022-06-30 | — | — | WO | disclosed |
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |