Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655785 | 0.89 | CYP26A1 (0.46) | PLK1PTGER4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29696137 | 0.81 | CYP26A1 (0.47) | PLK1PTGER4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13605449 | 0.75 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2MAOBHPGD | |
| SCHEMBL17664673 | 0.74 | CNR2 (0.44) | PLK1MEN1KMT2ALMNAGAA | |
| SCHEMBL29655544 | 0.74 | PTGER4 (0.46) | PTGER4NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL29655732 | 0.71 | NPC1 (0.62) | PTGER4NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL17960260 | 0.69 | PLK1 (0.43) | PLK1NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL5192592 | 0.68 | KMT2A (0.70) | NPC1RAB9ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL20861044 | 0.68 | TAS1R3 (0.63) | PLK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31189879 | 0.68 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2MAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138793-A1 | COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST | 小野薬品工業株式会社 | 2022-06-30 | — | — | WO | disclosed |
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |