Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568875 | 1.00 | SIRT6 (0.56) | SIRT6MAPTALDH1A1MAPK1POLB | |
| SCHEMBL2416849 | 0.86 | MAPT (0.69) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL3598727 | 0.86 | MAPT (0.69) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL20089103 | 0.85 | ALDH1A1 (0.72) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL17973907 | 0.82 | MAPT (0.47) | SIRT6MAPTALDH1A1MAPK1POLB | |
| SCHEMBL15971833 | 0.82 | SMN1; SMN2 (0.51) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL939117 | 0.82 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL15971829 | 0.82 | MAPT (0.52) | SIRT6MAPTALDH1A1MAPK1POLB | |
| SCHEMBL30574858 | 0.82 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1POLBTDP1 | |
| SCHEMBL29545794 | 0.82 | MAPT (0.56) | SIRT6MAPTALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |