Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.44 |
| ▸ | GRM5 | P41594 | 7/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | LIPC | P11150 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30778322 | 1.00 | NAMPT (0.50) | NAMPTPDK4NR1H2GRM1GRM5 | |
| SCHEMBL4564162 | 0.92 | NAMPT (0.50) | NAMPTPDK4NR1H2GRM1GRM5 | |
| SCHEMBL2946035 | 0.88 | NAMPT (0.51) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL29709692 | 0.88 | NAMPT (0.51) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL24793986 | 0.88 | NAMPT (0.51) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL27168139 | 0.88 | NAMPT (0.50) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL29976423 | 0.88 | NAMPT (0.50) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL30957987 | 0.87 | QDPR (0.52) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL520721 | 0.87 | QDPR (0.52) | NAMPTPDK4GRM1GRM5CYP11B2 | |
| SCHEMBL31129855 | 0.86 | NAMPT (0.51) | NAMPTPDK4GRM1GRM5CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460732-A | Pyrrolopyridone compounds, preparation method and application thereof | 杭州中美华东制药有限公司 | 2024-01-26 | — | — | CN | disclosed |
| WO-2022258044-A1 | PYRROLOPYRIDINONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-12-15 | — | — | WO | disclosed |
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |