Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22775472 | 1.00 | MAPT (0.50) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL22775709 | 0.90 | MAPT (0.51) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL29659773 | 0.90 | MAPT (0.51) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL3118574 | 0.83 | MAPT (0.61) | MAPTTP53RAB9ANPC1POLB | |
| SCHEMBL22775854 | 0.81 | MAPT (0.51) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL29431313 | 0.81 | MAPT (0.51) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL22787701 | 0.79 | MAPT (0.42) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL29431214 | 0.79 | MAPT (0.42) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL29613712 | 0.79 | MAPT (0.42) | MAPTTP53SMN1; SMN2MEN1STAT3 | |
| SCHEMBL17221764 | 0.79 | GAA (0.57) | MAPTTP53SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12552770-B2 | Compounds for treating respiratory disease | TMEM16A LIMITED (GB) | 2026-02-17 | — | — | US | disclosed |
| CN-114269721-B | Compounds for the treatment of respiratory diseases | TMEM16A有限公司 | 2024-12-20 | — | — | CN | disclosed |
| US-20220098167-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM16A LTD (GB) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12552770-B2 | Compounds for treating respiratory disease | TMEM109, SCN1A, SLC16A1 | MAPT 1158/4885TP53 4588/4885SMN1; SMN2 454/4885 |
| US-20220098167-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM109, SLC16A1, CFTR | MAPT 1182/4885TP53 4466/4885SMN1; SMN2 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.