Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 2/20 | 0.62 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.62 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17129984 | 1.00 | PARP15 (0.62) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL17129983 | 0.78 | MAPT (0.69) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL11750178 | 0.77 | TNKS2 (1.00) | PARP15PARP10TNKS2PARP2MAPT | |
| Hydrochloric Acid SCHEMBL10465281 | 0.77 | MAPT (0.67) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL13404813 | 0.77 | MAPT (0.44) | MAPTSMN1; SMN2LMNATP53RAB9A | |
| SCHEMBL19409255 | 0.76 | PARP15 (0.59) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL20893223 | 0.76 | IDO1 (0.46) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL11208936 | 0.76 | PARP2 (0.37) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL13394601 | 0.73 | MAPT (0.64) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL3590164 | 0.72 | CYP2A6 (0.38) | PARP15PARP10TNKS2PARP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | PARP15 2848/4885PARP10 2669/4885TNKS2 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.