Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30044683 | 0.86 | ANO1 (0.54) | ANO1GRM5FPR2GAALMNA | |
| SCHEMBL29660803 | 0.79 | ANO1 (0.56) | ANO1GRM5FPR2GAATDP1 | |
| SCHEMBL5836837 | 0.79 | GRM5 (0.54) | GRM5FPR2GAALMNAMAPT | |
| SCHEMBL7188498 | 0.79 | GRM5 (0.54) | GRM5FPR2GAALMNAMAPT | |
| SCHEMBL28911964 | 0.78 | GAA (0.51) | GRM5FPR2GAALMNAMAPT | |
| SCHEMBL4097011 | 0.77 | GRM4 (0.41) | ANO1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL1840355 | 0.75 | GAA (0.60) | GRM5FPR2GAALMNAMAPT | |
| SCHEMBL30043736 | 0.75 | GRM5 (0.57) | ANO1GRM5FPR2GAALMNA | |
| SCHEMBL29836003 | 0.74 | GRM5 (0.53) | ANO1GRM5FPR2GAALMNA | |
| SCHEMBL30043260 | 0.74 | ANO1 (0.59) | ANO1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003516-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | claimed |
| CN-114929683-A | Pyridine derivatives as calcium-activated chloride channel modulators | 跨膜蛋白16A有限公司 | 2022-08-19 | — | — | CN | disclosed |