SCHEMBL29664315

SCHEMBL29664315

COC(=O)c1ccc2nc(CCl)n(CC3(F)CC3)c2c1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ACSS2 Q9NR19 1/20 0.44
KDM4E B2RXH2 1/20 0.41
DRD2 P14416 2/20 0.40
TBXA2R P21731 2/20 0.40
KCNH2 Q12809 1/20 0.39
IDH1 O75874 6/20 0.39
ALDH1A1 P00352 2/20 0.38
ALOX15 P16050 1/20 0.38
HTT P42858 1/20 0.38
PKM P14618 1/20 0.38
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23363441 1.00 ACSS2 (0.44) ACSS2KDM4EDRD2TBXA2RKCNH2
SCHEMBL25340079 0.87 ACSS2 (0.43) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL29946034 0.87 ACSS2 (0.43) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL29149830 0.87 ACSS2 (0.44) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL29924345 0.87 ACSS2 (0.44) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL29555279 0.86 ACSS2 (0.44) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL25340969 0.86 ACSS2 (0.44) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL25322110 0.84 ACSS2 (0.42) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL30269530 0.84 ACSS2 (0.42) ACSS2KDM4EDRD2TBXA2RIDH1
SCHEMBL30686459 0.83 GLP1R (0.43) ACSS2KDM4EDRD2TBXA2RIDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4058445-B1 GLP-1 RECEPTOR AGONIST AND USE THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2025-03-26 EP disclosed
CN-114728939-B GLP-1 receptor agonists and uses thereof 日东制药株式会社 2023-12-08 CN disclosed
CN-114728939-A GLP-1 receptor agonists and uses thereof 日东制药株式会社 2022-07-08 CN disclosed