Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.64 |
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 7/20 | 0.64 |
| ▸ | HTT | P42858 | 7/20 | 0.64 |
| ▸ | TP53 | P04637 | 5/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | PTPRB | P23467 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17511740 | 0.96 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL1980247 | 0.94 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL28102527 | 0.94 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL16218976 | 0.94 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL2976178 | 0.91 | ALDH1A1 (0.69) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL2978401 | 0.86 | ALDH1A1 (0.71) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL27842842 | 0.85 | ALDH1A1 (0.64) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL15664687 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL1975310 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL1976898 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11701373-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701373-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701373-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-07-18 | — | — | US | disclosed |
| US-20220331346-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-10-20 | — | — | US | disclosed |
| US-11058696-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-13 | — | — | US | disclosed |
| US-11058696-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-13 | — | — | US | disclosed |
| EP-3183242-B1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-3183242-B1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20200281952-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-09-10 | — | — | US | disclosed |
| US-20200281952-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-09-10 | — | — | US | disclosed |
| US-9522888-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522888-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522888-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-20 | — | — | US | disclosed |
| US-20160052888-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2016-02-25 | — | — | US | disclosed |
| WO-2016028959-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-25 | — | — | WO | disclosed |
| US-8933195-B2 | Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments | NANJING YOKO BIOMEDICAL R & D LTD. (CN) | 2015-01-13 | — | — | US | disclosed |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | NANJING YOKO BIOMEDICAL R & D LTD. [CN/CN] (CN) | 2014-08-28 | — | — | US | disclosed |
| US-7767854-B2 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090082463-A1 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| EP-1884510-A1 | N-SUBSTITUTED PHENYLACETAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052888-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR2 | ALDH1A1 1696/4885MAPT 4700/4885LMNA 2847/4885 |
| US-20200281952-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR2 | ALDH1A1 1696/4885MAPT 4700/4885LMNA 2847/4885 |
| US-20220331346-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR2 | ALDH1A1 1696/4885MAPT 4700/4885LMNA 2847/4885 |
| US-20090082463-A1 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | HRH4, HRH2, CNR2 | ALDH1A1 321/4885MAPT 1590/4885LMNA 3880/4885 |
| US-11701373-B2 | Substituted bicyclic compounds | S1PR1, S1PR3, S1PR2 | ALDH1A1 1696/4885MAPT 4700/4885LMNA 2847/4885 |
| US-11058696-B2 | Substituted bicyclic compounds | S1PR1, S1PR3, S1PR2 | ALDH1A1 1696/4885MAPT 4700/4885LMNA 2847/4885 |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | HDAC1, HDAC11, HDAC2 | ALDH1A1 472/4885MAPT 4020/4885LMNA 1949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.