Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.68 |
| ▸ | AR | P10275 | 11/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spirorenone SCHEMBL8002313 | 1.00 | PGR (0.68) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL11028359 | 0.81 | PGR (0.51) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL13355946 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL13845352 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL13971411 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL14227067 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL13015156 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL18717263 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL22171517 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| Drospirenone SCHEMBL153317 | 0.81 | PGR (1.00) | PGRARLMNAABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247372-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022109161-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-05-27 | — | — | WO | disclosed |