Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.30 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.30 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.30 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.30 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.30 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25166328 | 0.72 | TOP2A (0.34) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL7037392 | 0.69 | TOP2A (0.39) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4747738 | 0.62 | TOP2A (0.39) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL31107851 | 0.61 | SOS1 (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL25166382 | 0.61 | SOS1 (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL20887704 | 0.60 | BRD4 (0.58) | — | |
| SCHEMBL4510713 | 0.60 | KDM4E (0.34) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL5723212 | 0.59 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7871976 | 0.58 | ALDH1A1 (0.41) | KDM4EKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL23714885 | 0.57 | LMNA (0.34) | KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478447-B | Benzo oxygen-containing ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-114478447-A | Benzo-oxygen-containing ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |